MCT4 contents in human skeletal muscles: Current Status
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چکیده
Running title: lactate transporters and exercise 3 Claire THOMAS, David J BISHOP, Karen LAMBERT, Jacques MERCIER, George 4 A. BROOKS 5 6 1 INSERM, U1046 “Physiologie et Médecine expérimentale du cœur et des muscles”, F7 34295 Montpellier, France 8 2 Université Evry Val d’Essonne, UFR Sciences fondamentales et appliquées, Département 9 STAPS, Bvd François Mitterrand, F-91025 Evry cedex, France 10 3 INSEP, Mission Recherche, Laboratoire de Biomécanique et Physiologie, Paris, France 11 4 Institute of Sport, Exercise and Active Living (ISEAL), Victoria University, Melbourne, 12 Australia 13 5 School of Sport and Exercise Science, Victoria University, Melbourne, Australia 14 6 CHU Montpellier, F-34295 Montpellier, France 15 7 Integrative Biology, University of California, Berkeley, CA, USA 94720-3140 16 17 Corresponding author: Claire Thomas, PhD-HDR 18 Université d’Evry Val d’Essonne, Département STAPS, 19 UFR des Sciences fondamentales et appliquées, 20 Bvd F. Mitterrand, 91025 Evry cedex, France 21 Phone: + 33 1 69 64 48 92 22 Fax: + 33 1 69 64 48 91 23 e-mail : [email protected] 24 25 Articles in PresS. Am J Physiol Regul Integr Comp Physiol (October 19, 2011). doi:10.1152/ajpregu.00250.2011
منابع مشابه
Effects of acute and chronic exercise on sarcolemmal MCT1 and MCT4 contents in human skeletal muscles: current status.
Two lactate/proton cotransporter isoforms (monocarboxylate transporters, MCT1 and MCT4) are present in the plasma (sarcolemmal) membranes of skeletal muscle. Both isoforms are symports and are involved in both muscle pH and lactate regulation. Accordingly, sarcolemmal MCT isoform expression may play an important role in exercise performance. Acute exercise alters human MCT content, within the f...
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